We develop and apply machine learning and statistical methods to study biology, including mechanisms of human health and disease. Most recently, we have been applying our methods to understand immune response(s) across different contexts, mechanisms of psychiatric disorders, and causes of rare genetic diseases in children. We are especially interested in developing models for combining association evidence across multiple types of molecular/genomoics data, such as gene expression and genotype data, and modeling prior biological pathways and networks for disentangling spurious from meaningful correlations.
To develop methods that lead to new biological insights, my group works closely with colleagues from varied disciplines, including immunology, neuroscience, genetics, psychiatry, and psychology. As some examples, we are part of the Child and Brain Development program through Canadian Insistute for Advanced Research (CIFAR), a core member of Immunological Genome (ImmGen) Consortium, and contributor to the Care4Rare project (a consortium for diagnosis of rare disease).
About Sara Mostafavi:
I am an Associate Professor at the Paul Allen School of Computer Science and Engineering at University of Washington (UW).
Before joining UW, I was an Assistant Professor at the Department of Statistics and the Department of Medical Genetics at University of British Columbia (UBC), and a faculty member at the Vector Institute. I also held a Canada Research Chair (CRC II) in Computational Biology (2015-2020), and a Canada CIFAR Chair in Artificial Intelligence (CIFAR-AI).
Before joining UBC, I did my postdoctoral fellowship with Daphne Koller at Stanford University. I got my PhD in Computer Science from the University of Toronto in 2011, working with Quaid Morris. My PhD thesis was on integrating large-scale genomics and proteomics datasets to predict gene function. Check out GeneMANIA to find out more about this project!
You can find my CV here and my google scholar page here.